Make history at Palazzo Portinari Salviati, a meticulously restored, 15th-century palace located in the heart of Florence. It’s like sleeping in a Renaissance museum, with art-filled courtyards and exquisite frescoes — not to mention jaw-dropping views of the Duomo. The 13 generous suites are elegantly appointed, with high frescoed or wood coffered ceilings. Original mosaics and a bubbling fountain set the mood in the Michelin-starred, locally focused restaurant. A full spa with ozone-therapy pool is housed in the underground vaults.